Evidence map›Paper›PMID 41141612›Full record

ArticleAmerican journal of preventive cardiology2025

Clinical, economic, and health care resource utilization burden of acute myocardial infarction and the role of systemic inflammation in US hospitals: A real-world study.

Lei Lv, Jeffrey R Skaar, Carey Robar, Sunday Ikpe, Shanthi Krishnaswami, Zhun Cao, Weilong Li, Michael G Nanna

Abstract read
In one paragraph

Article in American journal of preventive cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lei LvNovo Nordisk Inc., 800 Scudders Mill Rd, Plainsboro, NJ 08536, USA.
Jeffrey R SkaarNovo Nordisk Inc., 800 Scudders Mill Rd, Plainsboro, NJ 08536, USA.
Carey RobarNovo Nordisk Inc., 800 Scudders Mill Rd, Plainsboro, NJ 08536, USA.
Sunday IkpePremier Inc., 13034 Ballantyne Corporate Pl, Charlotte, NC 28277, USA.
Shanthi KrishnaswamiPremier Inc., 13034 Ballantyne Corporate Pl, Charlotte, NC 28277, USA.
Zhun CaoPremier Inc., 13034 Ballantyne Corporate Pl, Charlotte, NC 28277, USA.
Weilong LiNovo Nordisk Inc., 800 Scudders Mill Rd, Plainsboro, NJ 08536, USA.
Michael G NannaSection of Cardiovascular Medicine, Yale School of Medicine, 333 Cedar St, New Haven, CT 06510, USA.

Funding

Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Denise Esserman · 2002 to 2026
$37.9M
Estimating the treatment effect of cardiovascular medications to modify the risk for future cognitive decline in older adultsK76AG088428 · NIA · YALE UNIVERSITY · PI Michael Nanna · 2024 to 2026
$729k
NIA NIH HHS K76 AG088428NIA NIH HHS P30 AG021342
6 · The paper itself

Abstract

Background: Acute myocardial infarction (AMI), a leading cause of death in the US, is associated with significant clinical and economic burden. Systemic inflammation is a risk factor for worse cardiovascular outcomes, but the role of systemic inflammation in patients with AMI is not well established. Objective: To evaluate clinical, health care resource utilization (HCRU), and economic outcomes in patients with type 1 AMI, and explore results based on systemic inflammation status. Methods: Data from the Premier Healthcare Database were retrospectively analyzed, including adults with ≥1 inpatient hospitalization for type 1 AMI (using Results: Among patients with AMI ( Conclusion: Patients experiencing AMI, and especially those with evidence of systemic inflammation, experience persistently high risk of mortality, morbidity, recurrence, and large economic burdens. Greater attention is needed to optimize the care of this at-risk population.

Indexed as

Acute myocardial infarctionclinical burdenC-reactive proteineconomic burdenHealth care resource utilizationHigh-sensitivity C-reactive proteinSystemic inflammation

Identifiers

PMID41141612
PMCPMC12547950

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.