Evidence map›Paper›PMID 41141585›Full record

ArticleBioactive materials2026

Biomimetic bone niche reconstructs proliferation-inhibited and therapy-resistant bone-metastatic prostate cancer.

Xin Chen, Yujiao Peng, Ying Zhao, Huiling Liu, Qijun Lin, Xihong Fu, Lianheng Chen, Zhongte Peng, Jianfeng Huang, Yu Luo and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xin ChenDepartment of Orthopedic Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
Yujiao PengDepartment of Orthopedic Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
Ying ZhaoDepartment of Orthopedic Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
Huiling LiuOrthopaedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou 215006, China.
Qijun LinDepartment of Orthopedic Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
Xihong FuDepartment of Orthopedic Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
Lianheng ChenInstitute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 51000, China.
Zhongte PengInstitute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 51000, China.
Jianfeng HuangInstitute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 51000, China.
Yu LuoShanghai Engineering Research Center of Pharmaceutical Intelligent Equipment, Shanghai Frontiers Science Research Center for Druggability of Cardiovascular Non-coding RNA, Institute for Frontier Medical Technology, School of Chemistry and Chemical Engineering Shanghai University of Engineering Science, Shanghai, 201620, China.
Xuenong ZouDepartment of Orthopedic Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
Lei YangCenter for Health Sciences and Engineering, Hebei Key Laboratory of Biomaterials and Smart Theranostics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin, 300131, China.
Xinsheng PengDepartment of Orthopedic Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
Chun LiuInstitute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 51000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer bone metastases often harbor a rare subset of tumor cells with suppressed proliferation, contributing to therapy resistance and disease relapse. However, the lack of physiologically relevant

Indexed as

3D bioprintingBone microenvironmentDrug resistanceProstate cancer metastasisTumor dormancy

Identifiers

PMID41141585
PMCPMC12550310

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.