Evidence map›Paper›PMID 41141582›Full record

ArticleBioactive materials2026

Hydrogel delivering antifibrotic agent and nano-sonosensitizer enhances efficacy of sonodynamic therapy in osteosarcoma treatment.

Shanyi Lin, Hao Liu, Letian Lv, Guanyu Jin, Xinyu Xiang, Bingzheng Yu, Yuanzhen Su, Shucheng Zhang, Zijuan Wang, Zhaofan Yang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Multifunctional Shape-Memory Polyurethane/MnOMaterials (Basel, Switzerland) · 2026
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shanyi LinMusculoskeletal Tumor Center, Peking University People's Hospital, The Central Laboratory, Peking University School and Hospital of Stomatology, School of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Hao LiuMusculoskeletal Tumor Center, Peking University People's Hospital, The Central Laboratory, Peking University School and Hospital of Stomatology, School of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Letian LvMusculoskeletal Tumor Center, Peking University People's Hospital, The Central Laboratory, Peking University School and Hospital of Stomatology, School of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Guanyu JinMusculoskeletal Tumor Center, Peking University People's Hospital, The Central Laboratory, Peking University School and Hospital of Stomatology, School of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Xinyu XiangMusculoskeletal Tumor Center, Peking University People's Hospital, The Central Laboratory, Peking University School and Hospital of Stomatology, School of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Bingzheng YuMusculoskeletal Tumor Center, Peking University People's Hospital, The Central Laboratory, Peking University School and Hospital of Stomatology, School of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Yuanzhen SuMusculoskeletal Tumor Center, Peking University People's Hospital, The Central Laboratory, Peking University School and Hospital of Stomatology, School of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Shucheng ZhangMusculoskeletal Tumor Center, Peking University People's Hospital, The Central Laboratory, Peking University School and Hospital of Stomatology, School of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Zijuan WangMusculoskeletal Tumor Center, Peking University People's Hospital, The Central Laboratory, Peking University School and Hospital of Stomatology, School of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Zhaofan YangMusculoskeletal Tumor Center, Peking University People's Hospital, The Central Laboratory, Peking University School and Hospital of Stomatology, School of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Luyao WangDepartment of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun, 130031, Jilin, China.
Linlin LiuDepartment of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun, 130031, Jilin, China.
Shixian LvMusculoskeletal Tumor Center, Peking University People's Hospital, The Central Laboratory, Peking University School and Hospital of Stomatology, School of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Wei GuoMusculoskeletal Tumor Center, Peking University People's Hospital, The Central Laboratory, Peking University School and Hospital of Stomatology, School of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Yu GuoMusculoskeletal Tumor Center, Peking University People's Hospital, The Central Laboratory, Peking University School and Hospital of Stomatology, School of Materials Science and Engineering, Peking University, Beijing, 100871, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sonodynamic therapy (SDT) is an emerging modality for cancer treatment that induces immunogenic cell death (ICD) through reactive oxygen species (ROS) generation, thereby triggering potent antitumor immunity. However, the hypoxic and glutathione (GSH)-rich tumor microenvironment restricts ROS production, while dense extracellular matrix (ECM) formed by cancer-associated fibroblasts (CAFs) further impedes immune cell infiltration. Here, we developed a hydrogel-based localized delivery platform co-encapsulating the nano-sonosensitizer PCN-224@MnO

Indexed as

Cancer-associated fibroblastsHydrogelsOsteosarcomaPolymeric drug carriersSonodynamic therapies

Identifiers

PMID41141582
PMCPMC12550586

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.