Evidence map›Paper›PMID 41141562›Full record

ArticleArthroplasty today2025

Rheumatoid Arthritis Flare Presenting as Prosthetic Joint Infection With Synovial Next Generation Sequencing Guiding Treatment: A Case Report.

Jonathan Lash, Andrew Murphy, Marcus Voigt, Alexander Burbelo, Matthew Bullock

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthroplasty today, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jonathan LashDepartment of Orthopaedic Surgery, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.
Andrew MurphyDepartment of Orthopaedic Surgery, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.
Marcus VoigtDepartment of Orthopaedic Surgery, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.
Alexander BurbeloDepartment of Orthopaedic Surgery, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.
Matthew BullockDepartment of Orthopaedic Surgery, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A patient with rheumatoid arthritis (RA) experienced a flare that mimicked a prosthetic joint infection several years after undergoing total knee arthroplasty. She presented with gradual worsening knee pain following discontinuation of her RA medication. Elevated inflammatory markers and an increased synovial cell count were noted, but synovial fluid polymerase chain reaction testing was negative. A nonoperative treatment approach was chosen, and she resumed her RA medication which led to symptom resolution. Next-generation sequencing played a pivotal role in ruling out infection and identifying the rheumatic cause of the knee pain, thereby avoiding unnecessary revision surgery. Next-generation sequencing may be a valuable diagnostic tool in clinically ambiguous cases.

Indexed as

Culture-negative PJINext-generation sequencingProsthetic joint infectionRheumatoid arthritisTotal knee arthroplasty

Identifiers

PMID41141562
PMCPMC12547289

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.