ArticleEuropean heart journal. Case reports2025
Heart as white as stone, reborn: an unusual case report of idiopathic myocardial calcifications leading to end-stage heart failure and cardiac transplantation.
Article in European heart journal. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- From clinical observation to shared knowledge: the European Heart Journal Case Reports Cases of the year 2025.European heart journal. Case reports · 2026Article
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Authors and funding
5 authors.
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Abstract
Background: Massive myocardial calcifications without an underlying cause are a rare entity of unknown pathophysiology that could result in heart failure with preserved ejection fraction and restrictive physiology. The role of heart transplantation in these cases is unclear due to a lack of data and a concern that calcifications could reoccur in a transplanted organ. Case summary: We describe herein a 61-year-old patient who presented with new-onset heart failure with preserved ejection fraction. Multimodality imaging evaluation was consistent with restrictive cardiomyopathy secondary to massive myocardial calcifications. Extensive workup did not detect an underlying aetiology that could lead to development of myocardial calcifications. Eventually, at the age of 66, the patient underwent successful heart transplantation without evidence of calcification recurrence during a long-term follow-up of 9 years. Conclusion: Massive myocardial calcifications could result in end-stage heart failure. Heart transplantation might be considered a safe and reasonable therapeutic option in patients with idiopathic myocardial calcifications.
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