Evidence map›Paper›PMID 41141505›Full record

ArticleKidney international reports2025

Longitudinal Estimated GFR Trajectories Among Workers at High Risk for CKD of Unknown Etiology.

Jessica H Leibler, Fatima Tuz-Zahra, Ramón García-Trabanino, David J Friedman, Juan José Amador Velázquez, Emmanuel Jarquín, Damaris López Pilarte, Sinead A Keogh, Michael Light, Sophie E Claudel and 4 more

Abstract read
In one paragraph

Article in Kidney international reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jessica H LeiblerDepartment of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA.
Fatima Tuz-ZahraDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Ramón García-TrabaninoAgencia para el Desarrollo y la Salud Agropecuaria, El Salvador.
David J FriedmanBeth Israel Deaconess Medical Center and Harvard School of Medicine, Boston, Massachusetts, USA.
Juan José Amador VelázquezCentro Medico del Pacifico, Nicaragua.
Emmanuel JarquínAgencia para el Desarrollo y la Salud Agropecuaria, El Salvador.
Damaris López PilarteCentro Medico del Pacifico, Nicaragua.
Sinead A KeoghDepartment of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA.
Michael LightDepartment of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA.
Sophie E ClaudelBoston University School of Medicine, Boston, Massachusetts, USA.
Zoe E PetropoulosDepartment of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA.
Daniel R BrooksDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
Yorghos TripodisDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Madeleine K ScammellDepartment of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Chronic kidney disease (CKD) of unknown etiology is a leading cause of mortality among young men in Nicaragua and El Salvador, but longitudinal trends in kidney health and disease incidence remain poorly characterized. Methods: We estimated glomerular filtration rate (eGFR) among young adult male workers in Nicaragua and El Salvador without known CKD ( Results: Cumulative incidence was 4.5% ( Conclusion: In this prospective cohort, we observed declining eGFR, including rapid decline in a young and apparently healthy subgroup. Relying on incidence measures alone may underestimate poor kidney health in the context of CKD of unknown etiology.

Indexed as

chronic kidney diseasechronic kidney disease of uncertain etiologykidney function declinelongitudinal studyoccupational study

Identifiers

PMID41141505
PMCPMC12545559

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.