Evidence map›Paper›PMID 41141483›Full record

ArticleInternational journal of cardiology. Heart & vasculature2025

Individualized paced deep breathing training with autonomic nervous function as rehab targets in patients with chronic heart failure: a randomized clinical trial.

Xiaoling Liu, Ziwei Shan, Ting Shen, Megan Lo, Lin Luo, Qifan Sun, Lemin Wang, Guanghe Li, Yumei Jiang, Dejie Li and 4 more

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In one paragraph

Article in International journal of cardiology. Heart & vasculature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiaoling LiuDepartment of Rehabilitation, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Ziwei ShanDepartment of Rehabilitation, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Ting ShenDepartment of Rehabilitation, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Megan LoDepartment of Rehabilitation, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Lin LuoDepartment of Rehabilitation, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Qifan SunDepartment of Rehabilitation, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Lemin WangDepartment of Rehabilitation, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Guanghe LiDepartment of Rehabilitation, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Yumei JiangDepartment of Rehabilitation, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Dejie LiDepartment of Rehabilitation, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Mengyi ZhanDepartment of Rehabilitation, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Liang ZhengState Key Laboratory of Cardiovascular Diseases and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, China.
Jiankang WuSensor Networks and Application Research Center, School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, China.
Yuqin ShenDepartment of Rehabilitation, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The autonomic imbalance and low vagal tone are common characteristic among patients with chronic heart failure (CHF). It is hypothesized that CHF rehabilitation programs targeting autonomic nerves system (ANS) function may offer greater efficacy for CHF management. This trial represents the first attempt to investigate such an approach. Methods: This is a randomized controlled trial aimed to examine the effectiveness of individualized paced deep breathing training (IBT) in CHF patients, with ANS measures as rehabilitation targets. Patients in the IBT group received an additional 4-week program of IBT alongside their standard rehabilitation care. The cardiopulmonary resonance index (CRI), 6-Minute Walking Distance (6MWD) and the Minnesota Quality of Life Score Questionnaire (MLHFQ) were assessed at baseline (T1) and after 4 weeks (T2). Results: All 38 participants completed the trial successfully. Participants in the IBT group showed significant improvements in CRI, including enhancements in respiratory stability (RS), cardiopulmonary resonance amplitude (CRA), cardiopulmonary resonance factor (CRF), cardiopulmonary coupling coefficient (CPC), and the Spearman's Rank Correlation Coefficient between Respiratory Rate and Heart Rate (CRS). Further, improvements in both 6MWD and MLHFQ scores were observed. [Multiple linear regression analysis results showed correlations between RS and white blood cell (r = 0.924), CRF and procalcitonin (r = 0.733) and serum creatinine (r = 0.494), as well as CRS and glycosylated hemoglobin (r = 0.819)]. Conclusions: These findings demonstrate that IBT is a feasible and effective rehabilitation approach for CHF patients with ANS measures as target. The IBT program here also showed therapist efficiency and good patients compliance.

Indexed as

Autonomic nervous functionCardiopulmonary respiration testChronic heart failureIndividualized paced deep breathing training

Identifiers

PMID41141483
PMCPMC12553010

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.