Evidence map›Paper›PMID 41141435›Full record

ArticleJournal of the Canadian Association of Gastroenterology2025

Infections in primary sclerosing cholangitis and inflammatory bowel disease: a systematic review and meta-analysis.

Navneet Natt, Tyrel Jones May, Gurpreet Malhi, Jennifer Dumond, Aliya Gulamhusein, Parul Tandon

Abstract read
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In one paragraph

Article in Journal of the Canadian Association of Gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Navneet NattDivision of Gastroenterology, Department of Medicine, Western University, London, Ontario N6A 5C1, Canada.ORCID https://orcid.org/0000-0002-9465-7534
Tyrel Jones MayDivision of Gastroenterology and Hepatology, University Health Network, University of Toronto, Toronto, Ontario M5T 2S8, Canada.
Gurpreet MalhiDivision of Gastroenterology, Department of Medicine, Western University, London, Ontario N6A 5C1, Canada.
Jennifer DumondNorthern Ontario School of Medicine University, Thunder Bay, Ontario P7B 7A5, Canada.
Aliya GulamhuseinToronto Centre Liver for Disease, University Health Network, University of Toronto, Toronto, Ontario M5T 2S8, Canada.
Parul TandonDivision of Gastroenterology and Hepatology, University Health Network, University of Toronto, Toronto, Ontario M5T 2S8, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Primary sclerosing cholangitis (PSC) is a cholestatic liver disease that frequently coexists with inflammatory bowel disease (IBD). The risk of infections in patients with concurrent PSC-IBD remains unclear. The aim of this study was to identify the event rate of infections and associated risk factors in PSC-IBD patients. Methods: MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials were searched from inception to September 12, 2024 for studies examining event rate or risk factors for infection in patients with PSC-IBD. The primary outcome was the event rate of all-cause and site-specific infections as well as infection-related mortality. The secondary outcome was risk factors for infection. Random-effects models were used to calculate pooled odds ratios (OR) with 95% confidence intervals (CI) comparing the event rate of all-cause infections in PSC-IBD patients to those with just PSC and just IBD. Results: Eighty-one studies were included. The pooled event rate of all-cause infections in patients with PSC-IBD was 25.1% (95% CI, 17.0%-33.2%, Conclusion: Patients with PSC-IBD appear to be at increased risk of all-cause infection, sepsis, and mortality compared to those with IBD alone.

Indexed as

IBDinfectionsPSCPSC-IBD

Identifiers

PMID41141435
PMCPMC12551746

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.