ArticleFrontiers in neuroscience2025
Neural mechanism of HT7 electroacupuncture in myocardial ischemia: critical role of the paraventricular nucleus oxytocin system.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Electroacupuncture ameliorates chronic heart failure: the role of CRH neurons in the paraventricularnucleus of the hypothalamus.Frontiers in neuroscience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Electroacupuncture (EA) at Shenmen (HT7) alleviates acute myocardial ischemia (AMI), but its central neuromodulatory mechanisms remain insufficiently defined. This study investigated whether oxytocinergic (OT) neurons in the hypothalamic paraventricular nucleus (PVN) mediate the cardioprotective effects of EA and verified causality through chemogenetic interventions. Methods: Part I: C57BL/6 mice ( Results: EA at HT7 improved left ventricular ejection fraction ( Conclusion: PVN oxytocinergic neurons are both necessary and sufficient for the cardioprotective effects of EA at HT7. Chemogenetic regulation confirms a causal neurocardiac axis, providing mechanistic insights that support precision acupuncture therapies for ischemic heart disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.