ArticlePulmonary circulation2025
Jugular Venous Catheterization-Enhanced CT Angiography for In Vivo 3D Visualization of Cardiopulmonary Vasculature in Sprague-Dawley Rats.
Article in Pulmonary circulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Current in vivo imaging techniques for cardiopulmonary vascular evaluation in Sprague-Dawley (SD) rats face limitations, including structural disruption, inadequate contrast filling, and invasiveness. This study developed a reliable, minimally invasive computed tomography angiography (CTA) technique via jugular vein catheterization for enhanced cardiopulmonary vascular imaging in live SD rats. Jugular vein catheterization was performed in 22 anesthetized healthy male SD rats (320-480 g), followed by dual-source CT angiography with iopamidol contrast. Three-dimensional vascular reconstruction was performed, and pulmonary artery width alongside left and right ventricular diameters was measured. CT-derived measurements were compared with ultrasound data using Bland-Altman analysis. CTA achieved clear visualization of pulmonary arteries, cardiac chambers, and aortic structures, demonstrating complete contrast filling and anatomical detail. Three-dimensional reconstructions precisely delineated mediastinal and vascular relationships. Pulmonary artery widths measured by CT and ultrasound showed strong agreement (
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