Evidence map›Paper›PMID 41141401›Full record

ReviewNeurotrauma reports2025

Mapping the Landscape of Diaschisis in Traumatic Brain Injury: A Scoping Review.

Madison Evans, Cigdem Tosun, Ruchira M Jha, Prajwal Ciryam, Volodymyr Gerzanich, J Marc Simard

Abstract readReview
In one paragraph

Review in Neurotrauma reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Madison EvansDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Cigdem TosunDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Ruchira M JhaDepartment of Neurology, Barrow Neurological Institute and St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.ORCID https://orcid.org/0000-0002-3047-7649
Prajwal CiryamDepartment of Neurology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Volodymyr GerzanichDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
J Marc SimardDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diaschisis is a phenomenon in which damage to one brain region leads to dysfunction in remote, yet functionally connected, areas. Although it has been well characterized in stroke, the complex, multifocal nature of traumatic brain injury (TBI) suggests that similar network-level disruptions could occur, yet the presence and impact of diaschisis in TBI remain underexplored. This gap may stem from a historical focus on cerebrovascular events, underrecognition of diaschisis in TBI, and methodological challenges related to TBI's heterogeneous nature. This review maps diaschisis in TBI by examining models, mechanisms, neuroimaging, clinical features, and therapeutic interventions. A PRISMA-ScR guided search of PubMed, Embase, and Cochrane included studies explicitly addressing diaschisis in TBI from inception up to January 2025. Two independent reviewers screened titles, abstracts, and full texts, with discrepancies resolved by consensus. Twenty-three studies were included, encompassing 110 human participants, 497 animals, and one

Indexed as

brain mappingdiaschisisfunctional recoveryneural pathwaysneuroimagingtraumatic brain injury

Identifiers

PMID41141401
PMCPMC12549168

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.