Bipolar Disorder VII: Family History and Its Relationship With Suicide Attempts, Severity, and the Prophylactic Effect of Lithium Treatment in a Long-Term Follow-Up Study of Bipolar Disorder.

Per-Olof Nylander, Erik Lexne, Christer Lehman, Lars Brudin, Finn Bengtsson

Abstract read

In one paragraph

Article in Biological psychiatry global open science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Bipolar Disorder VI: Long-Term Follow-Up of Suicide Attempts and Prophylactic Effect of Lithium Treatment in Bipolar Affective Disorder.Biological psychiatry global open science · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Per-Olof NylanderLinköping University, Linköping, Sweden.

Erik LexneAcademic Clinic of Färjestaden, Färjestaden, Sweden.

Christer LehmanForensic Psychiatric Regional Clinic, Sundsvall, Sweden.

Lars BrudinDepartment of Medical and Health Science, Linköping University, Linköping, Sweden.

Finn BengtssonDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Family history (FH) of affective disorders (ADs) is important for the course of bipolar disorder (BD). Methods: In a long-term study (mean 25 years), 192 patients with BD diagnosed by DSM-IV criteria were recruited from lithium dispensaries. Differences between patients with and without an FH of ADs were studied. Results: Patients with an FH of AD had poorer lithium response ( Conclusions: BD patients with an FH of AD have a more severe form of BD with a special effect on SAs, AOO, episodes, and lithium response in BD.

Indexed as

Age of onsetBipolar disorderEpisodes of disorderFamily historyLithium drug therapy responseLong-term follow-upSuicide attempts

Identifiers

PMID41141386

DOI10.1016/j.bpsgos.2025.100608

PMCPMC12552958

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.