ReviewJournal of immunology research2025
The Role of Neuroinflammation in the Pathogenesis of Hepatic Encephalopathy.
Review in Journal of immunology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Central Administration of Recombinant IGF1 Is Neuroprotective in a Rodent Model of Acute Liver Failure.International journal of molecular sciences · 2026Article
- Association of the Albumin-Bilirubin score with 7-day incident delirium risk following bloodstream infection in critically ill adults: evidence from a propensity-weighted cohort.BMC infectious diseases · 2026Article
- Adiponectin Inhibits Oxidative Stress and Tight Junction Protein Loss: Evidence from a Hepatic Encephalopathy Mouse Model and Brain Endothelial Cells.Pharmaceuticals (Basel, Switzerland) · 2026Article
- The Role of Neuroinflammation in the Pathogenesis of Hepatic Encephalopathy.Journal of immunology research · 2025Review
- Gray matter microstructural alterations and their correlation with systemic biomarkers in hepatic encephalopathy: a NODDI study using gray-matter based spatial statistics.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Liver disease impacts millions of Americans every year, which is compounded by the comorbidities and consequences that patients are susceptible to developing. Hepatic encephalopathy (HE) is a severe consequence of liver failure resulting in a range of cognitive deficits that heavily impact quality of life. Approximately 40% of acute liver failure (ALF) patients and 50% of chronic liver disease patients will be diagnosed with HE, and the associated prognosis is 44% and 42%, respectively. Though understanding of some of the neurologic impacts of liver impairment exists, the pathology of HE is not yet fully elucidated. Many in the field have come to appreciate the role of neuroinflammation in its pathogenesis. In this review, we have summarized recent studies investigating aspects of neuroinflammation such as microgliosis, astrogliosis, proinflammatory cytokine and chemokine production, and the involvement of the choroid plexus and meninges in HE.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.