SynthesisFrontiers in endocrinology2025
Association of systemic immune-inflammation index with type 2 diabetes mellitus and its prognostic significance: a systematic review and meta-analysis.
Synthesis in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- The Association Between the HALP Score and Glycemic Control in Older Adults with Type 2 Diabetes Mellitus Receiving Home Health Care.Healthcare (Basel, Switzerland) · 2026Article
- Systemic Immune-Inflammatory Markers for Predicting Infarct Volume and Mortality in Patients with Acute Ischemic Stroke: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Metabolic Dysregulation, Inflammation, and Median Nerve Dysfunction in Patients with Type 2 Diabetes Mellitus with Carpal Tunnel Syndrome.International journal of molecular sciences · 2026Article
- Thermal-Inflammatory Index (TI): An Integrated Biomarker of Severity and Prognosis in Chronic Lower-Limb Ulcers.Biomedicines · 2026Article
- Comparative Longitudinal Evaluation of Systemic Inflammatory Markers in Type 2 Diabetes Treated with Four Oral Antidiabetic Drug Classes.Journal of clinical medicine · 2026Article
- The Role of Systemic Immune-Inflammation Index and Prognostic Nutritional Index in Predicting Outcomes of Chinese Patients with Diabetic Foot Ulcers After Moist Exposed Burn Ointment Treatment.International journal of general medicine · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The systemic immune-inflammation index (SII), a novel biomarker, may be associated with type 2 diabetes mellitus (T2DM). This study aimed to investigate the relationship between SII and T2DM, as well as its prognostic value. Methods: A comprehensive search of PubMed, Embase, Cochrane Library, Web of Science, CNKI, VIP, Wanfang, and Biomedical Literature Database was conducted to identify eligible studies published up to October 26, 2024. Relative risk (RR), odds ratio (OR), and hazard ratio (HR), along with their 95% confidence intervals (CIs), were extracted and synthesized. Statistical analyses were performed using Stata 15.1 software. Results: 21 studies were included. SII was associated with an increased risk of major adverse cardiovascular events (MACE) and mortality. Each one-unit standard deviation (SD) increase in SII was positively correlated with MACE risk (OR/HR = 1.07; 95% CI: 1.04-1.10; Conclusions: Elevated SII is associated with an increased risk of MACE, mortality, diabetic nephropathy and glucose metabolism abnormalities but shows no significant correlation with diabetic retinopathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.