ArticleFrontiers in endocrinology2025
Mechanistic insights into modified Danggui Buxue Decoction for diabetic retinopathy via integrative analysis.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study explores the therapeutic potential and mechanisms of Modified Danggui Buxue Decoction (MDBD) in diabetic retinopathy (DR) using network pharmacology, bioinformatics, machine learning, Mendelian randomization (MR), molecular docking, and Methods: A network pharmacology was constructed in order to screen core components and targets. Analysis of samples from the GEO database was performed for target and immune cell analysis, resulting in the identification of significantly differentially expressed core genes (SDECGs). A machine learning model was utilized to screen feature genes and construct nomogram. Preliminary validation was carried out using molecular docking, another GEO dataset, and MR. Subsequently, samples were clustered based on SDECGs expression and consensus clustering, followed by an analysis between clusters. SDECGs expression was scored and differences between clusters were analyzed. Finally, Results: This study identified the core components of MDBD, including quercetin, stigmasterol, beta-sitosterol, kaempferol, and 14 differentially expressed SDECGs between DR and control groups, with both positive and negative immune cell regulatory effects. Five feature genes (CCND1, ERBB2, INSR, TP53, SERPINE1) were identified and used to construct a predictive model. MR analysis revealed a causal link between elevated ERBB2 levels and increased DR risk (Odds Ratio [OR]=1.860, 95% CI: 1.247-2.774, Conclusion: MDBD treats DR by targeting SDECGs, modulating immune responses, and reducing inflammation. Beta-sitosterol and ERBB2 inhibition showed significant therapeutic effects, offering valuable insights for clinical application and future research directions.
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