ArticleFrontiers in endocrinology2025
Optimizing gestational diabetes diagnostic criteria to predict adverse perinatal outcomes in the United Arab Emirates: The Mutaba'ah Study.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Gestational diabetes mellitus (GDM) affects 25% of pregnancies in the United Arab Emirates (UAE), and there is a need for evidence-based diagnostic criteria. This study aimed to determine the optimal diagnostic criteria for GDM in the Emirati population based on predicting adverse perinatal outcomes. Methods: A total of 2,449 eligible pregnancies from "The Mutaba'ah Study" birth cohort were screened using OGTT between 24 and 32 weeks from May 2017 to March 2021. We compared the prediction of adverse perinatal outcomes [Large for Gestational Age (LGA) and Composite Outcome] risk by four GDM diagnostic criteria (IADPSG, NICE2015, WHO1999, and ADIPS1998) using adjusted regression models. We then developed a new GDM diagnostic threshold for this population (using an aOR of 1.75 recommended by the IADPSG consensus panel). The new criteria was validated and compared with other criteria using risk analyses, c-statistic (AUC), integrated discrimination improvement (IDI), and net reclassification improvement (NRI). Results: Of the four criteria assessed, IADPSG was the best predictor for large for gestational age (LGA) Conclusions: Following the development of a new threshold, the GDM diagnostic criteria defined in this study predicted adverse perinatal outcomes better and demonstrated more optimal clinical utility compared with the existing criteria in this population; hence, adopting it could minimize the burden of GDM adverse perinatal outcomes.
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