ArticleJRSM cardiovascular disease
The association between plasma levels of sCD40L, sP-selectin, and sICAM-1 and smoking-induced coronary heart disease: A cross-sectional study.
Article in JRSM cardiovascular disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to investigate the association between smoking and plasma levels of sCD40L, sP-selectin, and sICAM-1 in patients with coronary heart disease (CHD), and to evaluate their correlations with smoking intensity and coronary anatomical complexity assessed by the SYNTAX score. Methods: We analyzed data from 244 patients with CHD undergoing percutaneous coronary intervention, categorized into smokers (n = 150) and nonsmokers (n = 94). Smoking intensity was quantified using the smoking index (SI). Plasma biomarker levels were measured via ELISA. SYNTAX scores I and II were assessed by two experienced interventional cardiologists to evaluate coronary lesion complexity. Group comparisons, Spearman's correlation adjusted with the Benjamini-Hochberg method, tests for interaction (Gender × Smoking Status), and multivariate regression models were employed. Results: Smokers exhibited significantly higher sICAM-1 levels than nonsmokers (662.6 vs. 548.6 ng/ml, Conclusion: Elevated levels of sICAM-1, sCD40L, and sP-selectin are interrelated and associated with smoking intensity and coronary anatomical complexity, highlighting their role as key inflammatory mediators in smoking-related CHD.
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