ReviewFrontiers in bioengineering and biotechnology2025
Extended view on the mechanobiology of fracture healing: interplay between mechanics and inflammation.
Review in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Fracture healing: from molecular and cellular mechanisms to therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Patient-Specific Adaptation of a Mechano-Regulatory Bone-Healing Model Using Longitudinal Loading Data.Annals of biomedical engineering · 2026Article
- Mechanobiological Implications of Low-Young's Modulus TiNbSn Alloy Plates for Fracture Fixation: A Focused Review.Medical sciences (Basel, Switzerland) · 2026Review
- Biomechanical Comparison of Different Fixation Methods for Treating Jones Fracture of the Fifth Metatarsal.Bioengineering (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well established that the biomechanical environment guides bone regeneration. It is also commonly accepted that the early inflammatory phase of fracture healing is decisive for the later regeneration process by inducing angiogenesis, stem cell invasion and cartilage and bone tissue formation. While traditionally, biomechanical orchestration and inflammation were viewed as distinct phenomena, recent research has illuminated the intricate relationship between mechanics and inflammation in the mechanobiology of fracture healing. In this review, we summarize the current knowledge of how mechanical stimuli influence bone regeneration by inducing tissue differentiation, and we broaden the perspective on the mechanobiology of fracture healing by incorporating recent insights into the interaction between mechanical forces and inflammation-an emerging field termed as "mechano-immunomics." Key topics include the impact of fixation stiffness on immune cell migration and early gene expression of extracellular matrix-modulating genes, the influence of the mechanical environment within the early fracture hematoma on platelets and immune cells, and whether external biomechanical stimulation can alter the mechano-immunomic landscape. Gaining a deeper understanding of this dynamic interplay offers promising opportunities for innovative therapeutic strategies to enhance fracture healing. However, significant challenges remain, such as the development of suitable
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