ArticleFrontiers in nutrition2025
The fat-mass and obesity-associated gene rs9939609 T allele is prominent among the native Mexican population and is associated with risk for Type 2 diabetes and metabolic dysfunction-associated steatotic liver disease.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Molecular Mechanisms Associated with Metabolic Dysfunction: Contributions of Nutritional Genomics.Metabolites · 2026Review
- Role ofInternational journal of molecular sciences · 2026Article
- Genetic distribution of selected obesity-related SNVs in theFrontiers in genetics · 2026Article
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6 authors.
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Abstract
Background: The fat mass and obesity-associated ( Objective: This study aimed to determine the distribution of the Methods: In a cross-sectional study, 684 unrelated adults from West Mexico were included. Subjects were grouped as Amerindian (Wixárika and Nahuas) or admixed: Mestizo-Caucasians (Cuquío, San Miguel-Los Altos, and Villa Purificación) and Mestizo-Guadalajara (Mestizo-GDL). Results: The Wixárika group had the highest frequencies of the T allele (94%) and TT genotype (89%) among Amerindians, followed by mestizos from GDL (74% and 56%, respectively). In contrast, Mestizo-Caucasians from Cuquío had the highest A allele frequency (32.4%). No significant effect of the FTO genotype on body mass index (BMI)/body fat was observed in the Mestizo-GDL population. However, the TT carriers exhibited higher waist-to-height ratios (0.52 ± 0.07 vs. 0.49 ± 0.08), insulin levels (10.8 Conclusion: The
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