ReviewCureus2025
Mesenchymal Stem Cells in Pediatric Physeal Growth Arrest: A Systematic Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The physeal growth plate is a common site of involvement in pediatric and adolescent fractures, with 18-30% of fractures complicated by physis injury potentially leading to growth plate arrest and formation of a bony bar (BB). Inadequate treatment of growth arrest in children can cause long-term complications such as limb-length discrepancies or angular deformities. Stem cell transplantation has been increasingly studied as a potential treatment modality for growth arrest and prevention of BB formation in physeal injuries. The purpose of this study is to summarize the current state of literature on the ability of stem cells to prevent physeal growth arrest, determine the ideal stem cell type for use in physeal injuries, and analyze the methods of stem cell delivery and biochemical environment necessary for stem cell therapy success. This study is a systematic review. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were utilized to search PubMed including the terms "growth plate arrest", "physeal injury", "physeal", "growth plate injury", "bony bar", "stem cell", "mesenchymal", and "chondrocyte" from 2012-2024 and then independently analyzed by three reviewers. Studies were excluded if they were off topic, bench-top studies, editorials, non-English, or did not include a focus on stem cells. The search identified 269 potential articles, 68 remained after applying exclusion criteria, and eight were included after reviewer analysis. No studies in human models remained. Based on the findings of this systematic review, the use of mesenchymal stem cells and chondrocytes, when compared to controls, is associated with a decrease in bony deformities following injury to an open physeal growth plate in animal models. However, there is considerable variability in the literature on the method of stem cell transplantation and which combination of cells provides the greatest benefit. Given the high likelihood of limb deformity following pediatric or adolescent growth arrest injuries, utilizing mesenchymal stem cells to prevent growth arrest and BB formation would significantly impact the field of pediatric orthopedics. Stem cells have demonstrated the potential to improve outcomes in physeal plate injury in animal models; however, further research is needed to determine the ideal methods and biochemical environment required for successful stem cell therapy in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.