ReviewCureus2025
Environmental and Lifestyle Factors in the Risk and Prevention of Rheumatoid Arthritis: A Narrative Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune disease with a multifactorial etiology, driven by a combination of genetic susceptibility and modifiable environmental and exposure factors. While environmental factors such as cigarette smoke, occupational exposures, air pollution, and infections increase the risk of developing RA, lifestyle and dietary factors, including adherence to the Mediterranean diet and adequate vitamin D intake, may offer protective benefits. Systemic factors like obesity, chronic stress, and vitamin D deficiency also contribute to disease onset, highlighting the complex interplay of risk and protective elements in RA development. This narrative review synthesizes the existing literature on environmental and lifestyle factors associated with RA, focusing on modifiable risks and preventive strategies. A comprehensive literature search was conducted using PubMed and Google Scholar up to 2025, with Boolean combinations of terms related to RA and its environmental and lifestyle triggers. The review highlights the importance of minimizing exposures to environmental triggers and adopting lifestyle modifications, such as a Mediterranean diet, for RA prevention. Although medications like statins and hormone replacement therapy show mixed results, the need for a multifaceted approach combining environmental control, lifestyle changes, and early intervention is emphasized. Further research is needed to refine preventive strategies and deepen understanding of RA pathogenesis, ultimately improving outcomes for individuals at high risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.