ArticleJournal of diabetes and metabolic disorders2025
Mendelian randomization analysis: investigating the causal association between apoptotic proteins and diabetes.
Article in Journal of diabetes and metabolic disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Diabetes, commonly coexisting with hypertension, notably elevates the risk of damage to target organs. Apoptosis, a critical cellular process, maintains physiological balance but its role in the etiology of diabetes remains elusive. Study design: Mendelian randomization analysis. Methods: Utilizing summary data from genome-wide association studies (GWAS) of apoptotic proteins and diabetes, a two-sample Mendelian randomization (MR) design was employed. Our analysis included the Inverse Variance Weighted (IVW), weighted median, weighted mode, and MR-Egger regression. Sensitivity analyses included MR-Egger, MR-PRESSO, Cochran's Q test, and leave-one-out analyses, aimed at assessing and confirming the robustness and reliability of the research findings. Results: Our analysis revealed a suggestive positive correlation between increased Caspase-10 levels and heightened risk of type 1 diabetes (T1D) (OR 1.15, 95% CI 1.02-1.29, Conclusions: Our study illuminates the genetic causal ties between apoptotic proteins and the susceptibility to essential hypertension and diabetes. These insights are foundational for advancing our comprehension of disease mechanisms, facilitating preventive measures, and opening new horizons for precision medicine targeting these pathways. Supplementary Information: The online version contains supplementary material available at 10.1007/s40200-025-01771-w.
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