ArticleBioactive materials2026
Integrated 3D printing of topologically hierarchical mechanical hydrogel for accelerating osteochondral regeneration.
Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- From Mechanism to Therapy: Establishing an Integrated Framework for the Regulation and Intervention of Matrix Vesicles in Vascular Calcification.Cardiovascular drugs and therapy · 2026Review
- A novel PCL fiber membrane with a gradient structure for guided bone regeneration.RSC advances · 2026Article
- A decoupling strategy toward spatiotemporal regulation and biomechanical transmission of sandwiched scaffold for osteochondral regeneration.Nature communications · 2026Article
- The Role of 3D Printing in Regenerative Medicine: A Game-Changer in Tissue Engineering.International journal of molecular sciences · 2026Review
- Clinical outcomes and feasibility of 3D-printed titanium alloy scaffolds combined with platelet-rich plasma injection in the treatment of long-segment femoral defects.BMC research notes · 2026Article
- Hydrogels for Osteochondral Interface Regeneration: Biomaterial Types, Processes, and Animal Models.Gels (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteochondral defects present a formidable clinical challenge due to the intricate structural and functional interdependence of cartilage and subchondral bone. Conventional scaffolds, characterized by single-scale, disconnected pores, inherently restrict cell-cell communication and nutrient diffusion, thereby impeding osteoblast-to-osteocyte transformation and matrix mineralization. Herein, a 3D-printed topologically hierarchical mechanical hydrogel (THMH) scaffold was developed featuring a biomimetic bilayer architecture that recapitulates the native osteochondral microenvironment. THMH integrates a nanoporous cartilage-mimetic layer and a macroporous osteogenic layer, interconnected via gradient pores to facilitate nutrient transport, vascularization, and cellular crosstalk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.