Evidence map›Paper›PMID 41140916›Full record

ArticleIDCases2025

Ganciclovir-resistant CMV encephalitis in a mantle cell lymphoma patient on pirtobrutinib: Case report.

Rebecca Unterborn, Karrine Brade, Steven M Bair, Chia-Yu Chiu

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in IDCases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rebecca UnterbornDivision of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Karrine BradeDepartment of Pharmacy, University of Colorado Hospital, Aurora, CO, USA.
Steven M BairDivision of Hematology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Chia-Yu ChiuDivision of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Funding

CANCER CLINICAL EPIDEMIOLOGY TRAINING GRANTT32CA009679 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Richard Aplenc, Karen Glanz · 1992 to 2026
$11.1M
NCI NIH HHS T32 CA009679
6 · The paper itself

Abstract

Cytomegalovirus (CMV) infection in patients with hematologic malignancies who have not undergone stem cell transplantation remains poorly understood. Reports of clinically significant CMV infections in patients receiving Bruton Tyrosine Kinase inhibitors (BTKi) are rare. We present a case of ganciclovir-resistant CMV encephalitis in a patient with mantle cell lymphoma (MCL) treated with pirtobrutinib (a third generation BTKi). This case highlights the importance of maintaining a high index of suspicion for CMV infection in patients with hematologic malignancies, including those receiving therapies traditionally considered to carry a lower risk of opportunistic infections.

Indexed as

Bruton tyrosine kinase inhibitorCase reportCytomegalovirusGanciclovir-resistanceMantle cell lymphomaPirtobrutinib

Identifiers

PMID41140916
PMCPMC12547932

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.