ArticleCurrent developments in nutrition2025
Effects of 8-Week High-Intensity Interval Training Intervention Regulating the SIRT1/PGC1α Pathway on Hippocampal Neuron Injury and Cognitive Impairment in Obese Rats.
Article in Current developments in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Voluntary Exercise and Hippocampal Memory Enhancement: Decoding the Molecular Blueprint.Journal of molecular neuroscience : MN · 2026Review
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8 authors.
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Abstract
Background: Obesity can causes changes in cognitive function, leading to cognitive impairment (CI). Objectives: This study aimed to explore the effects of high-intensity interval training (HIIT) on hippocampal neuronal damage, cognitive function, and the SIRT1/PGC1α pathway in obese rats and provide a theoretical basis for HIIT intervention in improving CI caused by obesity. Methods: Rats with successful obesity modeling and rats of the same age were randomly divided into a normal quiet group (CSG, Results: Compared with the normal quiet group, the exercise group showed a significant decrease in body weight and Lee index, whereas the obesity group showed a significant increase. The Morris water maze experiment showed that compared with the CSG, the HSG had a longer latency period and a reduced number of platform crossings. The latency period of the CEG was shortened, and the frequency increased. Compared with the HSG, the HEG had a shorter latency period and an increase in frequency. Organizational staining showed that the HSG had reduced neuron number, deepened staining, chaotic arrangement, and Nissl body lysis in the hippocampal CA1 region, whereas HIIT improved these pathological changes. RT-qPCR showed obesity reduces the mRNA level of Conclusions: An 8-wk HIIT can reduce hippocampal neuronal damage and CI in obese rats, and the specific mechanism may improve neuronal pathological damage and restore cognitive function by activating the SIRT1/PGC1α pathway.
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