Evidence map›Paper›PMID 41140900›Full record

ArticleOphthalmology science2026

Baseline Relationships between Visual Function and Inflammatory Markers in the Registry of Moderated-Stage Retinitis Pigmentosa.

Takahiro Hisai, Sakurako Shimokawa, Masatoshi Fukushima, Kohta Fujiwara, Yoshito Koyanagi, Akie Hirata, Atsushi Takada, Fuyuka Miyahara, Naoki Nakashima, Yuko Kobayakawa and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Takahiro HisaiDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Sakurako ShimokawaDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Masatoshi FukushimaDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kohta FujiwaraDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yoshito KoyanagiDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Akie HirataDepartment of Medical Informatics, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Atsushi TakadaMedical Information Center, Kyushu University Hospital, Fukuoka, Japan.
Fuyuka MiyaharaMedical Information Center, Kyushu University Hospital, Fukuoka, Japan.
Naoki NakashimaDepartment of Medical Informatics, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yuko KobayakawaCenter for Clinical and Translational Research, Kyushu University Hospital, Fukuoka, Japan.
Go MawatariDepartment of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Masataka IshizuDepartment of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Naoki ToyamaMiyata Eye Hospital, Miyazaki, Japan.
Tomoko KaidaMiyata Eye Hospital, Miyazaki, Japan.
Kazunori MiyataMiyata Eye Hospital, Miyazaki, Japan.
Yasuhiro IkedaDepartment of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Koh-Hei SonodaDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yusuke MurakamiDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To analyze the association between visual function and inflammatory markers in the baseline data of a prospective natural history registry of patients with typical retinitis pigmentosa (RP) (Retinitis Pigmentosa Progression and Inflammatory Marker Registry Study [RP-PRIMARY Study]). Design: A cross-sectional observational study using baseline data from the RP-PRIMARY study. Participants: A total of 67 patients with moderate-stage typical RP who were treated between October 2021 and October 2022 in 1 of 3 participating hospitals consented to participate and met the inclusion criteria. Methods: Visual functions were ETDRS best-corrected visual acuity (BCVA), Humphrey Field Analyzer 10-2 program (mean deviation value, and the mean sensitivity within the central 1° area [central 4 points, RS Cent 1'] and the 4° area [central 12 points, RS Cent 4']), ellipsoid zone (EZ) length, central foveal thickness (CFT), hyper-autofluorescence (AF) ring area, and inflammatory markers were aqueous flare and blood test measurements. Main Outcome Measures: Association between visual function and inflammatory markers. Results: The median age of participants was 51 (interquartile range: 43-60) years. Spearman rank correlation coefficient demonstrated that aqueous flare values were negatively correlated with ETDRS BCVA (ρ = -0.35; Conclusions: In the baseline data of the RP-PRIMARY study, aqueous flare, an ocular inflammatory marker, was negatively associated with visual function, and IOL implantation was most strongly associated with an increase in aqueous flare in patients with moderate-stage RP. The association between inflammatory markers and disease progression will be evaluated in the ongoing RP-PRIMARY study. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

Aqueous flareProspective studyRegistry dataRetinitis Pigmentosa

Identifiers

PMID41140900
PMCPMC12553051

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.