Evidence map›Paper›PMID 41140878›Full record

ArticleExploration of targeted anti-tumor therapy2025

Synergistic anticancer efficacy of optimized curcumin-piperine loaded magnetic nanoparticles for the treatment of colorectal cancer.

Ritika Puri, Vimal Arora

Abstract read
In one paragraph

Article in Exploration of targeted anti-tumor therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ritika PuriUniversity Institute of Pharma Sciences, Chandigarh University, Gharuan 140413, Punjab, India.ORCID https://orcid.org/0000-0002-4029-212X
Vimal AroraUniversity Institute of Pharma Sciences, Chandigarh University, Gharuan 140413, Punjab, India.ORCID https://orcid.org/0000-0001-9520-138X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: The current study uses the depicted approach to synthesize curcumin-piperine loaded Poloxamer F-68 coated magnetic nanoparticles (CUR-PIP-F68-Fe Methods: A Box-Behnken design was employed to optimize the CUR-PIP-F68-Fe Results: Results showed that the optimised nanoparticles possessed a particle size of 158.7 ± 0.057 nm, zeta potential of -30.3 ± 0.1 mV, and encapsulation efficiency of 98.85 ± 0.066%. Analysis by vibrational sample magnetometer revealed that magnetic saturation was 75.6 emu/g and 50.7 emu/g for bare Fe Conclusions: The combination approach of curcumin-piperine magnetic nanoparticles to HCT-116 cells enhanced the anticancer efficacy of the curcumin and further demonstrated the potential of this approach to conduct in vivo studies.

Indexed as

curcuminHCT-116 colon cell linemagnetic nanoparticlespiperinesynergistic effect

Identifiers

PMID41140878
PMCPMC12550504

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.