Evidence map›Paper›PMID 41140824›Full record

ArticleNagoya journal of medical science2025

Potential effects of microglia-vascular interactions during chronic systemic inflammation in the central nervous system of mice with systemic lupus erythematosus.

Mariko Shindo, Takahiro Tsuji, Rahadian Yudo Hartantyo, Yutaro Saito, Ayaka Ito, Shouta Sugio, Ikuko Takeda, Takayoshi Suganami, Hiroaki Wake

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nagoya journal of medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mariko ShindoDepartment of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Takahiro TsujiDepartment of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Rahadian Yudo HartantyoDepartment of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yutaro SaitoDepartment of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Ayaka ItoDepartment of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Shouta SugioDepartment of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Ikuko TakedaDepartment of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Takayoshi SuganamiDepartment of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Hiroaki WakeDepartment of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microglia are brain specific macrophages and the only immune cells in the brain. Microglia sense the systemic immune status and contribute to neurological and psychiatric disorders. We previously showed that systemic immune activation induces microglial migration on vessels that regulate the blood brain barrier permeability. In this study, using Toll like receptor 7 induced systemic lupus erythematosus model mice, we found microglia migration on vessels and significant T cell infiltration in the brain. Additionally, microglia interacting with T cell expressed MHC class II molecules in some cases, suggesting the antigen presentation of microglia in systemic lupus erythematosus model mice. This research provides insights on the autoimmune antibody expression in the brain.

Indexed as

BrainInflammationLupus Erythematosus, SystemicMicrogliaAnimalsBlood-Brain BarrierDisease Models, AnimalFemaleHistocompatibility Antigens Class IIMiceT-LymphocytesToll-Like Receptor 7Histocompatibility Antigens Class IIToll-Like Receptor 7imiquimodmicroglianeurodegenerative diseasessystemic lupus erythematosusT cell infiltration

Identifiers

PMID41140824
PMCPMC12549116

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.