ArticleJournal of surgical case reports2025
Primary closure of ileostomy site after irrigation with betaine-polyhexanide: a case series.
Article in Journal of surgical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Surgical site infection (SSI) remains a major concern after ileostomy closure, limiting the adoption of primary closure despite the cosmetic and practical advantages of primary closure. A 0.1% betaine-0.1% polyhexanide solution, a surfactant-disinfectant solution with biofilm-disrupting properties, has been shown to significantly reduce SSI rates in various acute and chronic wounds throughout the body. This single-institution case series is the first in the literature to evaluate SSI rates with the use of betaine-polyhexanide irrigation and primary closure of ileostomy sites. All patients demonstrated well-healed incisions without SSI, wound dehiscence, or other wound-related complications at their follow-up visits 10-48 days post-operatively. Compared to the historically high SSI rates with ileostomy site primary closure, this study's findings suggest that betaine-polyhexanide irrigation may allow for safe primary closure while preserving its advantages of reduced wound care burden and improved cosmesis.
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