ArticleJournal of inflammation research2025
Serum miR-27a Reduction and FOXO3 Elevation in Elderly Patients with Severe Pneumonia Complicated with ARDS: Association with Disease Severity and Prognosis.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- miR-211-5p/FOXO3 axis accelerates osteogenic differentiation and fracture healing by mediating Wnt/β-catenin pathway.Journal of orthopaedic surgery and research · 2026Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Objective: To clarify the expression of microRNA-27a (miR-27a) and forkhead box protein O3 (FOXO3) in elderly patients with severe pneumonia complicated with acute respiratory distress syndrome (ARDS), and evaluate their relationship with disease severity and prognosis. Methods: A total of 189 elderly patients with severe pneumonia were retrospectively analyzed, including 114 with ARDS (Group A) and 75 without ARDS (Group B). Seventy healthy individuals served as controls. Group A was further divided into mild (n=28), moderate (n=36), and severe (n=50) subgroups based on oxygenation index, and into survival (n=79) and death (n=35) subgroups based on 28-day outcome. Serum miR-27a and FOXO3 mRNA were measured by qRT-PCR. Their correlations with oxygenation index and prognosis were analyzed using Pearson, Spearman, logistic regression, and ROC curve methods. Results: Serum miR-27a levels decreased and FOXO3 mRNA levels increased progressively from controls to Group B and Group A (F=77.352, 62.956, P<0.001). Within Group A, miR-27a declined and FOXO3 rose stepwise with increasing ARDS severity (F=83.597, 111.834, P<0.001). MiR-27a was negatively correlated with FOXO3 (r=-0.624, P<0.001), positively with oxygenation index (r=0.635, P<0.001), while FOXO3 showed the opposite pattern (r=-0.672, P<0.001). The 28-day mortality was 30.7%. Logistic regression identified age, prolonged ventilation, and high FOXO3 as risk factors, while higher oxygenation index and elevated miR-27a were protective. The AUCs for mortality prediction were 0.775 (miR-27a), 0.781 (FOXO3), and 0.867 (combined). Conclusion: Reduced miR-27a and elevated FOXO3 are characteristic of elderly patients with severe pneumonia and ARDS, closely linked to disease severity and prognosis. Combined detection improves predictive accuracy, supporting their potential as biomarkers for survival evaluation.
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