SynthesisFrontiers in medicine2025
Research trends of intestinal barrier in ulcerative colitis: a bibliometric analysis.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Knowledge structure and paradigm evolution in anal fistula diagnosis and treatment: a bibliometric analysis based on PubMed.Updates in surgery · 2026Article
- Clinical trajectories after preoperative traditional Chinese medicine in biologic-refractory surgery- intended acute severe ulcerative colitis: an exploratory retrospective case series.Frontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Ulcerative colitis (UC) is intricately associated with the dysfunction of the intestinal barrier, making the restoration of barrier integrity a promising therapeutic target. Nonetheless, there is a notable deficiency in comprehensive and systematic investigations in this domain. Methods: A total of 1,554 articles were extracted from the Web of Science Core Collection (WoSCC) and Scopus. We employed analytical tools such as CiteSpace and VOSviewer to identify leading topics and create visual representations of countries/regions, institutions, authors, keyword networks, and journals pertinent to this field of study. Results: Since 2020, there has been a marked increase in the annual publication rate, with China accounting for 72.13% of the total output. In terms of international collaboration patterns, China and the United States form the core cooperative system, which has served as the foundation for establishing a globalized research collaboration network. Frequently occurring keywords underscore the application of traditional Chinese medicine, repair of tight junctions, and the NF-κB/oxidative stress pathway. Contemporary studies are increasingly emphasizing targeted delivery and clinical translation, with epithelial barriers and organoid models emerging as prominent research foci. Influential publications have primarily concentrated on the pathological mechanisms and experimental models related to UC, while the journal "Inflammatory Bowel Diseases" has proven to be an essential platform for the dissemination of knowledge within this sphere. Conclusion: The intestinal barrier has surfaced as a significant therapeutic target for UC, fostering a multidisciplinary research network. Future endeavors should aim at enhancing the linkage between mechanistic studies and clinical implementations to yield improved practical outcomes. Additionally, promoting a more equitable distribution of international collaborations is vital for the advancement of targeted intervention strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.