ArticleFrontiers in medicine2025
Correlation of tear cortisol levels with morphological and biomechanical parameters of keratoconus.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Introduction: Keratoconus (KC) is a vision-threatening corneal disorder predominantly affecting young males, significantly impairing their quality of life. We aim to evaluate tear cortisol levels in KC and compare with controls, and to determine the correlation of tear cortisol levels with morphological and biomechanical parameters of KC. Methods: Age- and sex-matched 42 eyes of 42 patients were enrolled. The levels of tear cortisol were obtained by liquid chromatography-tandem mass spectrometry. Pentacam HR and Corvis ST II were used to detect the corneal morphological and biomechanical parameters. Spearman correlations between tear cortisol levels and corneal parameters were calculated for all patients. Results: Comparing with the control group, the level of tear cortisol significantly increased in the KC group (1660.95 [1175.01-2408.81] vs. 945.60 [550.36-1699.32], Conclusion: Our findings demonstrate that tear cortisol levels are significantly associated with some corneal morphological and biomechanical parameters in KC, suggesting its potential role as a pathogenic factor, thereby providing new insights into the exploration of disease pathogenesis.
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