ArticleFrontiers in medicine2025
Is calprotectin a reliable marker in surgical ICU settings? A clinical evaluation of its role in sepsis and mortality prediction.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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4 authors.
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Abstract
Background: Calprotectin, a neutrophil-derived protein, has emerged as a potential biomarker for inflammation and infection. This study evaluated the utility of serum calprotectin levels in diagnosing sepsis and predicting mortality in surgical intensive care unit (ICU) patients. Methods: This prospective observational study included 124 patients admitted to the surgical ICU at Uşak Training and Research Hospital between 2022 and 2024. Data on demographics, serum calprotectin, CRP, PCT, lactate levels, and clinical scores (SOFA, APACHE II) were collected. ROC analysis was used for predictive accuracy; Spearman and Pearson correlation coefficients assessed associations. Results: No significant associations were found between serum calprotectin and SOFA/APACHE II scores, CRP, or lactate. However, calprotectin correlated positively with PCT in sepsis ( Conclusion: Calprotectin alone lacks sufficient diagnostic or prognostic power for sepsis in surgical ICU patients. It may serve as a complementary marker alongside PCT in specific subgroups.
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