ArticleRSC advances2025
Conformational change-based electrochemical biosensor for the simple and highly selective detection of miRNA in whole serum.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
MicroRNAs (miRNAs) have emerged as powerful biomarkers for early-stage disease detection and prognosis support. However, their reliable quantification in complex biological fluids remains a significant challenge. Here, we present a simple and robust electrochemical DNA (E-DNA) sensor for the direct detection of miRNA-29c in whole human serum. The sensing mechanism harnesses the conformational change that occurs upon miRNA hybridization to the immobilized DNA capture probe. By exploiting the intrinsic base-pairing specificity of nucleic acids, our system achieves high selectivity, while the conformational change-based sensing mechanism confers resistance to electrode fouling. This dual advantage enables sensitive miRNA detection in complex media and effective discrimination of closely related miRNA sequences. Under optimized conditions, the biosensor exhibited a sigmoidal response to miRNA-29c in whole serum across the concentration range of 0.1-100 nM and showed excellent agreement with the Langmuir-Hill model (
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