Evidence map›Paper›PMID 41140468›Full record

ArticleFrontiers in chemistry2025

Antibacterial effects of coniferyl alcohol-derived dehydrogenation polymer on chlamydial infection

Anna Pfundner, Tamara Weinmayer, Nora Geissler, Ana Kovacevic, Dragica Spasojevic, Ksenija Radotic, Marijana Stojanovic, Irma Schabussova, Ursula Wiedermann, Aleksandra Inic-Kanada

Erratum issuedAbstract read
In one paragraph

Article in Frontiers in chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Anna PfundnerInstitute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Tamara WeinmayerInstitute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Nora GeisslerInstitute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Ana KovacevicInstitute of Immunology, Virology, Vaccines and Sera - Torlak, Belgrade, Serbia.
Dragica SpasojevicInstitute for Multidisciplinary Research, University of Belgrade, Belgrade, Serbia.
Ksenija RadoticInstitute for Multidisciplinary Research, University of Belgrade, Belgrade, Serbia.
Marijana StojanovicInstitute for Biological Research "Siniša Stanković" - National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Irma SchabussovaInstitute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Ursula WiedermannInstitute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Aleksandra Inic-KanadaInstitute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Material and Methods: The cytotoxicity of DHP/Alg on A2EN genital epithelial cells was assessed by measuring cell viability. To investigate its effects on Results: No cytotoxic effects of DHP/Alg in tested concentrations on A2EN cells were observed, confirming its safety. Infection and adhesion assays demonstrated a significant reduction in infection levels, suggesting that DHP/Alg directly targets Conclusion: Our results suggest that DHP/Alg is a promising therapeutic option against chlamydial infections. The significant reduction in adhesion levels indicates that DHP/Alg effectively interferes with the initial stages of infection.

Indexed as

chlamydial infectionChlamydia trachomatisdehydrogenation polymerligninsexually transmitted infectiontreatment

Identifiers

PMID41140468
PMCPMC12550777

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.