Evidence map›Paper›PMID 41140467›Full record

ArticleFrontiers in chemistry2025

Elucidating multifaceted targets of Marein in cerebral ischemia-reperfusion injury.

Weidan Luo, Jian Wang, Ying Fan, Meng Yuan, Wanying Xie, Yang Su, Xingchun Wang, Yi Zhong, Yibo Zhang, Jiaxin Zhan and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Weidan Luo *Department of Neurology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Jian Wang *Department of Comprehensive (VIP) Inpatient Ward, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Ying FanDepartment of Neurology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Meng YuanDepartment of Neurology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Wanying XieDepartment of Neurology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Yang SuDepartment of Neurology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Xingchun WangThe Affiliated Stomatological Hospital of Southwest Medical University, Southwest Medical University, Luzhou, Sichuan, China.
Yi ZhongDepartment of Neurology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Yibo ZhangDepartment of Neurology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Jiaxin ZhanDepartment of Neurology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Xuan MaoDepartment of Neurology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Xinyao HuangDepartment of Neurology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Junxi LongDepartment of Neurology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Xinrui WangDepartment of Neurology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Tingting TangDepartment of Neurology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Xingxia WangDepartment of Neurology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cerebral ischemia-reperfusion injury (CIRI) is a major pathological event in stroke, leading to neuronal damage and neuroinflammation. Marein, a flavonoid derived from Methods: Marein-related targets were predicted using SwissTargetPrediction, and cerebral ischemia-reperfusion injury (CIRI)-related targets were obtained from GeneCards. Common targets were identified by Venn analysis, followed by protein-protein interaction network construction and GO/KEGG enrichment analysis. Molecular docking and 100-ns molecular dynamics simulations evaluated interactions between Marein/Edaravone and key targets (PTGS2, SRC, EGFR). Results: 64 common targets (including PTGS2, SRC, EGFR) were identified. Enrichment analyses highlighted involvement in calcium signaling, inflammatory responses. Molecular docking and dynamics confirmed stable binding of Marein to PTGS2, SRC, and EGFR, with favorable binding free energies. Conclusion: Marein exerts neuroprotective effects against CIRI by targeting PTGS2, SRC, and EGFR, modulating inflammatory and oxidative stress pathways. This study provides a mechanistic basis for Marein's potential in CIRI therapy.

Indexed as

cerebral ischemia-reperfusion injuryMareinmolecular dockingmolecular dynamics simulationnetwork pharmacology

Identifiers

PMID41140467
PMCPMC12547697

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