Evidence map›Paper›PMID 41140443›Full record

ArticleBlood neoplasia2025

MNT: a new target for AML.

Karla C Fischer, Veronique Litalien, Sarah T Diepstraten, Michelle Jahja, Fiona C Brown, Gemma L Kelly, Andrew H Wei, Suzanne Cory

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood neoplasia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Karla C FischerWalter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Veronique LitalienWalter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Sarah T DiepstratenWalter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Michelle JahjaWalter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Fiona C BrownWalter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Gemma L KellyWalter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Andrew H WeiWalter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Suzanne CoryWalter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deregulated expression of the transcription factor c-MYC is well established as a primary driver of diverse tumor types. In this study, for the first time to our knowledge, we show that mouse and human myeloid leukemias provoked by oncogenic mixed lineage leukemia (MLL) fusion proteins are dependent on the MYC family member MNT (MAX network transcriptional repressor), which is highly expressed in these AMLs. To investigate the role of MNT, we generated

Identifiers

PMID41140443
PMCPMC12549552

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.