Evidence map›Paper›PMID 41140432›Full record

ArticleJournal of neurological surgery. Part B, Skull base2025

Effectiveness of Preoperative Antiseptic Preparation in Transnasal Skull Base Surgery: A Randomized Three-Arm Controlled Trial.

Abdulrazag Ajlan, Abdullah Alatar, Sarah Bin Abdulqader, Ashwag Alqurashi, Sarah Basindwah, Faisal Farrash, Lolo Aldhwaihy, Basim M Noor Elahi, Abdulaziz S Alrasheed, Abdulaziz Alqahtani and 9 more

Abstract read
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In one paragraph

Article in Journal of neurological surgery. Part B, Skull base, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Abdulrazag AjlanDivision of Neurosurgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.ORCID 0000-0003-1725-339X
Abdullah AlatarDivision of Neurosurgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Sarah Bin AbdulqaderDepartment of Neurosurgery, National Neuroscience Institute, King Fahad Medical City, Riyadh, Saudi Arabia.
Ashwag AlqurashiDivision of Neurosurgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Sarah BasindwahDivision of Neurosurgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Faisal FarrashDepartment of Neuroscience, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Lolo AldhwaihyDivision of Neurosurgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Basim M Noor ElahiDivision of Neurosurgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Abdulaziz S AlrasheedDepartment of Otolaryngology - Head & Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Abdulaziz AlqahtaniDepartment of Otorhinolaryngology, King Fahad Medical City, Riyadh, Saudi Arabia.
Ahmad AlroqiDepartment of Otolaryngology - Head & Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Ghassan AlokbyDepartment of Otolaryngology-Head and Neck Surgery, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
Gmaan AlzhraniDepartment of Neurosurgery, National Neuroscience Institute, King Fahad Medical City, Riyadh, Saudi Arabia.
Saud AlromaihDepartment of Otolaryngology - Head & Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Mohammed BafaquhDepartment of Neurosurgery, National Neuroscience Institute, King Fahad Medical City, Riyadh, Saudi Arabia.
Othman AlhammadDepartment of Neuroscience, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Abdullah AlobaidDepartment of Neurosurgery, National Neuroscience Institute, King Fahad Medical City, Riyadh, Saudi Arabia.
Fahad AlFawwazDepartment of Otorhinolaryngology, King Fahad Medical City, Riyadh, Saudi Arabia.
Saad AlsalehDepartment of Otolaryngology - Head & Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Transnasal skull base surgery is a complex and invasive procedure that involves the use of preoperative antiseptic preparations. However, evidence supporting their use in preventing postoperative infectious complications is limited. The aim of this study is to assess the efficacy of preoperative antiseptic techniques in reducing postoperative infectious complications within 30 days of surgery. Methods: A multicenter, prospective, randomized, single-blind, three-arm trial was conducted from February 2019 to October 2021. Participants were randomized to either of three antiseptic preparation techniques: external 0.9% NaCl nasal preparation, external 0.05% chlorhexidine gluconate, or intranasal irrigation with 80 mg of gentamicin added to 1,000 mL of 0.9% NaCl plus external nasal preparation with chlorhexidine gluconate 0.05%. A total of 130 adults with skull base pathologies were randomized; 12 were excluded before randomization for failure to meet the inclusion criteria ( Results: The mean age of the participants was 43.26 ± 14.45 years. Nine patients developed postoperative infections (meningitis, Conclusion: Preoperative antiseptic techniques failed to prefer one application to prevent postoperative infectious complications in patients who underwent endoscopic transnasal skull base surgery.

Indexed as

antisepsismeningitissinusitisskull base

Identifiers

PMID41140432
PMCPMC12552038

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.