Evidence map›Paper›PMID 41140394›Full record

ArticleFrontiers in microbiology2025

Exploring Greek actinobacterial biodiversity for the discovery of bioactive metabolites with skin antiaging potential.

Konstantinos Gaitanis, Eirini Gkogkou, Paris Laskaris, Nikolaοs Tsafantakis, Despoina D Gianniou, Stavroula I Kaili, Georgia C Ntroumpogianni, Aikaterini Theodosopoulou, Nikola Milic, Dimitris G Hatzinikolaou and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Konstantinos Gaitanis *Division of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.
Eirini Gkogkou *Division of Cell Biology and Biophysics, Department of Biology, National and Kapodistrian University of Athens, Athens, Greece.
Paris Laskaris *Division of Botany, Department of Biology, National and Kapodistrian University of Athens, Athens, Greece.
Nikolaοs TsafantakisDivision of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.
Despoina D GianniouDivision of Cell Biology and Biophysics, Department of Biology, National and Kapodistrian University of Athens, Athens, Greece.
Stavroula I KailiDivision of Botany, Department of Biology, National and Kapodistrian University of Athens, Athens, Greece.
Georgia C NtroumpogianniDivision of Botany, Department of Biology, National and Kapodistrian University of Athens, Athens, Greece.
Aikaterini TheodosopoulouDivision of Cell Biology and Biophysics, Department of Biology, National and Kapodistrian University of Athens, Athens, Greece.
Nikola MilicDivision of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.
Dimitris G HatzinikolaouDivision of Botany, Department of Biology, National and Kapodistrian University of Athens, Athens, Greece.
Nikolas FokialakisDivision of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.
Ioannis P TrougakosDivision of Cell Biology and Biophysics, Department of Biology, National and Kapodistrian University of Athens, Athens, Greece.
Amalia D KaragouniDivision of Botany, Department of Biology, National and Kapodistrian University of Athens, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Actinobacteria are a rich secondary metabolite source, accounting for nearly half of known bioactive microbial compounds, thus representing promising targets for novel bioactive molecule discovery. To explore potential antiaging compounds, we screened extracts from 980 actinobacterial strains isolated from diverse Greek ecosystems. Extracts were evaluated for elastase and tyrosinase inhibition

Indexed as

actinobacteriaantioxidant activityautophagy activationbioactive metaboliteselastase inhibitionskin agingtyrosinase inhibitionubiquitin-proteasome system

Identifiers

PMID41140394
PMCPMC12546214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.