ArticleFrontiers in microbiology2025
Emergence of high-risk ST595 and ST640 clones of carbapenem-resistant
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Genome-Guided Dissection of ser and shlB Uncovers Multifactorial Virulence Mechanisms of Serratia marcescens PXG6 in Plutella xylostella.Environmental microbiology · 2026Article
- From Environmental Organism to Nosocomial Threat:Antibiotics (Basel, Switzerland) · 2026Review
- Molecular Epidemiology of Carbapenem-ResistantInfection and drug resistance · 2026Article
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8 authors.
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Abstract
Objective: Carbapenem-resistant Methods: A total of 52 CRSM clinical isolates collected during a nosocomial outbreak were subjected to whole-genome sequencing (WGS) for comprehensive analysis of virulence factor (VF) profiles, sequence types (STs), and phylogenetic relationships. Based on genomic clustering, representative isolates were selected for Results: All the CRSM carried Conclusion: This study provides the first integrated genomic and phenotypic characterization of CRSM during a documented hospital outbreak, highlighting ST595 and ST640 as high-risk clones with distinct virulence signatures. The convergence of rapid growth, biofilm capacity, and serum resistance in select isolates underscores their potential role in prolonged colonization and nosocomial spread. These findings emphasize the urgent need for genomic surveillance and targeted infection control strategies to curb the dissemination of emerging CRSM clones.
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