Evidence map›Paper›PMID 41140063›Full record

ArticleThe American journal on addictions2025

Brief report: Opioid withdrawal in patients with cirrhosis: A retrospective cross-sectional United States analysis.

Christopher Behrend, Alexandra D Ferreira, Spencer R Goble

Abstract read
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In one paragraph

Article in The American journal on addictions, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christopher BehrendDepartment of Medicine, Hennepin Healthcare, Minneapolis, Minnesota, USA.
Alexandra D FerreiraDepartment of Medicine, University of Minnesota Medical School Twin Cities Campus, Minneapolis, Minnesota, USA.
Spencer R GobleDepartment of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0003-2076-2670

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesPatients with cirrhosis face poor outcomes for numerous acute pathologies, but opioid withdrawal outcomes in this population are unknown.

methodsWe conducted a retrospective cross-sectional study of 306,455 hospitalizations for opioid withdrawal within the National Inpatient Sample from 2016 to 2022.

resultsPatients with cirrhosis (n = 2415) had increased rates of mechanical ventilation (aOR = 2.34, p = .004), death (aOR = 4.24, p = .022) and cost (mean $7845 vs. $4409, p < .001). CONCLUSION AND SCIENTIFIC SIGNIFICANCE: This is the first large, generalizable study of opioid withdrawal in cirrhosis, showing worse outcomes and underscoring the need for careful monitoring in this population.

Indexed as

Analgesics, OpioidHospitalizationLiver CirrhosisOpioid-Related DisordersSubstance Withdrawal SyndromeAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedRespiration, ArtificialRetrospective StudiesUnited StatesAnalgesics, Opioid

Identifiers

PMID41140063
PMCPMC12555094

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.