ArticleDrug development research2025
Curcumin Alleviates Sepsis-Associated Acute Kidney Injury Potentially by Inhibiting Ferroptosis Through the ACSL4/GPX4 Signaling Pathway.
Article in Drug development research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- Targeting integrated cell death networks in sepsis‑associated acute kidney injury: Shared regulatory nodes and diet‑related small molecule modulation (Review).International journal of molecular medicine · 2026Review
- Folate-Targeted Co-Delivery of Curcumin and siRela Nanoparticles Synergistically Treat Sepsis-Associated Acute Kidney Injury.ACS omega · 2026Article
- Article
- Curcumin Alleviates Sepsis-Associated Acute Kidney Injury Potentially by Inhibiting Ferroptosis Through the ACSL4/GPX4 Signaling Pathway.Drug development research · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
This study aimed to investigate the protective effect of curcumin against sepsis-associated acute kidney injury (SA-AKI) in vitro and in vivo, and to clarify the role of ferroptosis in this protection. Human renal tubular epithelial cell (RTEC) line HK-2 was stimulated with lipopolysaccharide (LPS). Ferroptosis was further induced with erastin. In vivo, a rat SA-AKI model was produced by cecal ligation and puncture (CLP) and allocated to the Sham, sepsis, and curcumin (Cur) + sepsis (Sep) groups. Glutathione (GSH), malondialdehyde (MDA), and pro-inflammatory cytokines were quantified by ELISA. Western blot analysis was used to evaluate the ferroptosis-related proteins, including long-chain acyl-coenzyme synthetases 4 (ACSL4) and glutathione peroxidase 4 (GPX4). Apoptosis of RTECs was assessed with TUNEL staining, and ultrastructural changes were examined by transmission electron microscopy (TEM). Compared with the Sepsis group, the Cur + Sep group showed significantly lower Paller damage scores, reduced Scr, BUN, TNF-α, IL-1β, IL-6, MDA, Fe
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Registered trials
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