Evidence map›Paper›PMID 41139953›Full record

ArticleOncoimmunology2025

Simultaneous secretion of a PD-L1 x 4-1BB bispecific antibody improves antileukemic efficacy of STAb-T cells secreting a CD19-specific T-cell engager.

Marina Gómez-Rosel, Laura Rubio-Pérez, Ivana Zagorac, Carmen Domínguez-Alonso, Laura Díez-Alonso, Oana Hangiu, Rocío Navarro, Raúl Torres-Ruíz, Sandra Rodríguez-Perales, Francisco J Blanco and 3 more

Abstract read
In one paragraph

Article in Oncoimmunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marina Gómez-RoselCancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0001-8816-9844
Laura Rubio-PérezCancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0002-2877-6092
Ivana ZagoracCancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0002-7135-8283
Carmen Domínguez-AlonsoCancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0002-0446-9629
Laura Díez-AlonsoCancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0002-9545-6910
Oana HangiuCancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0002-2641-8531
Rocío NavarroDepartment of Antibody Engineering, Leadartis SL, QUBE Technology Park, Tres Cantos, Madrid, Spain.ORCID 0000-0002-0083-7711
Raúl Torres-RuízMolecular Cytogenetics Group, Human Cancer Genetics Program, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.
Sandra Rodríguez-PeralesMolecular Cytogenetics Group, Human Cancer Genetics Program, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.
Francisco J BlancoInstituto de Biomedicina de Valencia (IBV), CSIC, Valencia, Spain.ORCID 0000-0003-2545-4319
Marta CompteDepartment of Antibody Engineering, Leadartis SL, QUBE Technology Park, Tres Cantos, Madrid, Spain.ORCID 0000-0002-7138-9266
Luis Álvarez-VallinaCancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0003-3053-6757
Belén BlancoCancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0001-5085-7756

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adoptive therapy with CAR-T cells and systemic administration of bispecific T-cell engagers (TCE) have achieved unprecedented success in the treatment of relapsed/refractory (R/R) B-cell malignancies. However, high relapse rates remain a major challenge. STAb (

Indexed as

Antibodies, BispecificAntigens, CD19B7-H1 AntigenImmunotherapy, AdoptiveT-LymphocytesTumor Necrosis Factor Receptor Superfamily, Member 9AnimalsCell Line, TumorFemaleHumansMiceXenograft Model Antitumor AssaysAntibodies, BispecificAntigens, CD19B7-H1 AntigenCD19 molecule, humanCD274 protein, humanTumor Necrosis Factor Receptor Superfamily, Member 94-1BB costimulationbispecific antibodiesPD−1/PD-L1 blockersSTAb-T cells

Identifiers

PMID41139953
PMCPMC12562732

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.