ArticleAngewandte Chemie (International ed. in English)2025
Spatial Assembly of Mechanically Planar Chiral Rotaxanes on Rationally Designed Cavitands.
Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- A General and Scalable Chiral Surrogate Rotaxane Strategy for Highly Enantioenriched Mechanically Planar Chiral Rotaxanes.Angewandte Chemie (International ed. in English) · 2026Article
- Atroposelective Bromination for the Synthesis of Chiral Biaryl Phosphines via Cross-Assembled Catalysis with Chiral Phosphoric Acid and Achiral Phenol.Journal of the American Chemical Society · 2026Article
- Spatial Assembly of Mechanically Planar Chiral Rotaxanes on Rationally Designed Cavitands.Angewandte Chemie (International ed. in English) · 2025Article
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4 authors.
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Abstract
Chirality plays a central role in chemistry, biology, and pharmaceutical sciences. Although covalent chirality is widely studied, stereoselective assembly of mechanically interlocked molecules (MIMs) remains challenging. Herein, we report a spatial assembly strategy for the stereoselective synthesis of mechanically planar chiral (MPC) rotaxanes. Rationally designed inherently chiral cavitands orchestrate the spatial arrangement of macrocycle and axle components during mechanical interlocking. This approach enables high levels of stereocontrol in both active-template and passive-template synthesis of MPC rotaxanes (up to 93:7 e.r.). Our study demonstrates that stereoinduction of MIMs can be made predictable through rational design of chiral auxiliaries, paving the way for applications of the spatial assembly strategy in asymmetric supramolecular synthesis.
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