Evidence map›Paper›PMID 41139796›Full record

ReviewMicrobial cell factories2025

Advances in biomanufacturing and recent biological applications of the fundamental bacterial carotenoids: a comprehensive review.

Khaled B Al-Monofy, Mahmoud H Farghali, Lamiaa A Al-Madboly, Amal M Abo Kamer, Ahmed A Abdelaziz

Abstract readReview
In one paragraph

Review in Microbial cell factories, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Journal of microbiology and biotechnology · 2026
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Khaled B Al-MonofyDepartment of Microbiology and Immunology, Faculty of Pharmacy, Tanta University, Tanta, Egypt. khaled.ahmed@pharm.tanta.edu.eg.
Mahmoud H FarghaliDepartment of Microbiology and Immunology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Lamiaa A Al-MadbolyDepartment of Microbiology and Immunology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Amal M Abo KamerDepartment of Microbiology and Immunology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Ahmed A AbdelazizDepartment of Microbiology and Immunology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many research teams have prioritized the investigation of the biotechnological production of carotenoids in the last few decades due to their multipurpose application. In this review, the bioproduction of the fundamental bacterial carotenoids, including lycopene, β-carotene, β-cryptoxanthin, zeaxanthin, canthaxanthin, and astaxanthin, is discussed, along with detailed information on their biosynthesis, laboratory screening, physiochemical requirements, genetic engineering-based production development, and fermentation techniques. As well, this review emphasizes that the bacterial carotenoids are innovative therapeutic avenues with diverse biological applications, from food additives to anticancer agents. Moreover, the review discusses the limitations of the application of these carotenoids and the future perspectives. Ultimately, the review highlights the bacteria as powerful cell factories, potentially facilitating the commercial production of carotenoids in the future.

Indexed as

BacteriaCarotenoidsBiotechnologyFermentationGenetic EngineeringHumansCarotenoidsBacterial pigmentsBiological applicationsCarotenoidsGenetic engineeringNatural pigmentsProduction optimization

Identifiers

PMID41139796
PMCPMC12557945

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.