Evidence map›Paper›PMID 41139778›Full record

ArticleJournal of nanobiotechnology2025

Dual-function MgSrCeAl-LDH nanosheets enable both ROS clearance and enhanced angiogenesis for myocardial ischemia/reperfusion injury therapy.

Jiayi Shen, Yuwen Luo, Wuming Hu, Susu Zhang, Yu Yang, Linwen Lan, Enqian Liu, Jian Xu, Tingting Hu, Jingjun Nie and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jiayi Shen *Department of Cardiology, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Central Hospital, Lishui, 323000, P. R. China.
Yuwen Luo *Laboratory of Bone Tissue Engineering, Beijing Laboratory of Biomedical Materials, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, National Center for Orthopaedics, Capital Medical University, Beijing, 100035, P. R. China.
Wuming Hu *Department of Cardiology, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Central Hospital, Lishui, 323000, P. R. China.
Susu Zhang *Department of Cardiology, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Central Hospital, Lishui, 323000, P. R. China.
Yu YangState Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
Linwen LanDepartment of Cardiology, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Central Hospital, Lishui, 323000, P. R. China.
Enqian LiuDepartment of Cardiology, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Central Hospital, Lishui, 323000, P. R. China.
Jian XuDepartment of Cardiology, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Central Hospital, Lishui, 323000, P. R. China.
Tingting HuDepartment Electrical Engineering, City University of Hong Kong, 83 Tat Chee Ave, Kowloon Tong, 999077, Hong Kong SAR, P. R. China.
Jingjun NieLaboratory of Bone Tissue Engineering, Beijing Laboratory of Biomedical Materials, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, National Center for Orthopaedics, Capital Medical University, Beijing, 100035, P. R. China.
Dafu ChenLaboratory of Bone Tissue Engineering, Beijing Laboratory of Biomedical Materials, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, National Center for Orthopaedics, Capital Medical University, Beijing, 100035, P. R. China. chendafu@jst-hosp.com.cn.
Ruizheng LiangState Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, P. R. China. liangrz@buct.edu.cn.
Lingchun LyuDepartment of Cardiology, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Central Hospital, Lishui, 323000, P. R. China. lvlingchun@medmail.com.cn.

Funding

Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes JYY2023-11, JYY2023-8Fundamental Research Funds for the Central Universities of Beijing University of Chemical Technology XK1803-05Lishui City Public Welfare Technology Application Research Project 2024GYX53, 2024GYX48National Natural Science Foundation of China 22288102National Natural Science Foundation of China 52373128Zhejiang Provincial Medical and Health Science Project 2025KY482, 2025KY483, 2025KY1917
6 · The paper itself

Abstract

Myocardial ischemia/reperfusion (I/R) injury represents a major global health concern, driven by excessive reactive oxygen species (ROS), which closely correlates with subsequent myocardial infarction and fibrosis. Combining ROS scavenging with ischemic myocardium revascularization holds therapeutic promise. However, developing multifunctional therapeutic agents that can simultaneously scavenge ROS and promote angiogenesis remains unreported. Herein, we propose MgSrCeAl-layered double hydroxide (LDH) nanosheets as a multifunctional ROS scavenger and angiogenesis promoter for efficient myocardial I/R injury treatment. MgSrCeAl-LDH nanosheets not only exhibit exceptional hydroxyl radicals (·OH) and superoxide anions (·O

Indexed as

HydroxidesMyocardial Reperfusion InjuryNanostructuresNeovascularization, PhysiologicReactive Oxygen SpeciesAngiogenesisAnimalsCeriumHumansMaleMiceMyocardiumRatsCeriumHydroxidesReactive Oxygen SpeciesAngiogenesisLayered double hydroxidesMyocardial ischemia/reperfusionReactive oxygen species

Identifiers

PMID41139778
PMCPMC12557895

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.