SynthesisJournal of robotic surgery2025
Comparing quality of life after robot assisted versus open radical cystectomy: A systematic review.
Synthesis in Journal of robotic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBladder cancer is a common malignancy in both sexes. Robot-assisted approaches are increasingly used in its surgical management. Radical cystectomy can significantly affect health-related quality of life (HRQoL), typically assessed using patient-reported outcome measures (PROMs) that capture patients' physical, psychological, and social well-being.
objectivesTo systematically compare HRQoL and functional outcomes following robot-assisted versus open radical cystectomy (RARC vs. ORC) for bladder cancer, and to evaluate the methodologies employed, including PROMs and postoperative assessment timepoints.
methodsA systematic search of CENTRAL, Embase, PubMed, and Scopus (2000-2025) was performed for randomised and non-randomised studies comparing HRQoL outcomes after RARC and ORC. Eligible studies reporting PROM-based HRQoL were included. Data were extracted on patient characteristics, PROMs, and outcome domains, and synthesised descriptively.
resultsNine studies involving 1,575 patients met inclusion criteria. Seven HRQoL domains were identified, assessed using 18 PROMs; the EORTC QLQ-C30 was most frequently applied (n = 4). HRQoL was typically assessed at 3, 6, and 12 months, with only one study extending beyond 12 months. Functional assessment was limited: one study employed the Internation Index of Erectile Function (IIEF-5) for male erectile function, none assessed female sexual function, and one reported objective continence outcomes. Across studies, no statistically significant differences in HRQoL were observed between RARC and ORC. However, heterogeneity in PROMs, inconsistent outcome reporting, and high risk of bias limited comparability.
conclusionsCurrent evidence does not demonstrate a HRQoL advantage of RARC over ORC. Standardisation of PROMs, consistent follow-up intervals, and inclusion of functional domains are essential to strengthen comparative evidence and inform the role of RARC as a potential new standard of care.
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