SynthesisInfluenza and other respiratory viruses2025
Burden of RSV in Young Children in High-Income Countries: Incidence Estimates From a Multilevel Meta-Analysis in Primary and Emergency Care.
Synthesis in Influenza and other respiratory viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Burden of RSV in Young Children in High-Income Countries: Incidence Estimates From a Multilevel Meta-Analysis in Primary and Emergency Care.Influenza and other respiratory viruses · 2025Pooled it
- Nirsevimab reduced acute otitis media infections in infants-a nationwide interrupted time-series analysis.European journal of pediatrics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundMost respiratory syncytial virus (RSV) infections in children are managed in primary care settings, including ambulatory care and emergency departments (EDs). This study provides adjusted pooled RSV incidence estimates for children under 5 years in primary care settings in high-income countries (HICs).
methodsWe used population-based RSV incidence rates from 27 studies collected in a previous systematic review as input parameters. To adjust for heterogeneity in study design, we assessed the impact of four key factors: 1) age, 2) primary care setting (ambulatory care or EDs), 3) data collection period (year-round or seasonal), and 4) study methodology (cohort studies with laboratory-confirmed RSV, healthcare databases, surveillance data). In the final model, we corrected for age, primary care setting, and study methodology. Adjusted pooled RSV incidence estimates were calculated using a multilevel logit-logistic regression model.
resultsFor children < 5 years, the adjusted pooled RSV incidence estimate in primary care settings was 62.8 per 1000 population (95% CI 45.3-86.6). Incidence was higher in ambulatory care (108.1 per 1000; 95% CI 78.0-148.0) compared to EDs (35.8 per 1000; 95% CI 25.3-50.3). Age-stratified incidence estimates declined with increasing age, showing 86.5 (95% CI 61.6-120.2), 80.3 (95% CI 57.1-111.8), 60.7 (95% CI 43.2-84.6), and 36.5 (95% CI 25.4-52.2) per 1000 for children aged < 6 months, 0-1 year, 0-2 years, and 0-5 years, respectively.
conclusionsThis is the first multilevel meta-analysis estimating the RSV-related burden in primary care settings, including both ambulatory and emergency care. These results can be used by decision makers for the introduction of RSV immunization programs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.