ArticleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2025
Aripiprazole Has Potential Efficacy for Antidepressant-induced Restless Legs Syndrome: A Case Series.
Article in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The study aims to report that a lower dose of aripiprazole ameliorates restless legs syndrome (RLS) induced by antidepressants. We report 3 cases of RLS associated with antidepressants. We differentiated the symptoms from akathisia due to diurnal variation and focused sensation in the legs and evaluated them using the International Restless Legs Syndrome Severity Rating Scale. In all cases, the symptoms deteriorated under antidepressant treatment. In one case, this may have been due to discontinuation of aripiprazole. According to the presented cases and literature, we concluded that aripiprazole has efficacy for secondary RLS induced by antidepressants.
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