Evidence map›Paper›PMID 41139450›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2025

[Pinostrobin targets the PI3K/AKT/CCL

Keni Zhang, Tong Qiao, Lin Yin, Ju Huang, Zhijun Geng, Lugen Zuo, Jianguo Hu, Jing Li

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Keni ZhangDepartment of Clinical Laboratory,First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
Tong QiaoDepartment of Clinical Laboratory,First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
Lin YinDepartment of Clinical Laboratory,First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
Ju HuangCentral Laboratory,First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
Zhijun GengCentral Laboratory,First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
Lugen ZuoAnhui Provincial Key Laboratory of Basic and Translational Research on Inflammatory Diseases, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
Jianguo HuDepartment of Clinical Laboratory,First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
Jing LiDepartment of Clinical Laboratory,First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the mechanism through which pinostrobin (PSB) alleviates dextran sulfate sodium (DSS)-induced colitis in mice.

methodsC57BL/6 mice were randomized into control group, DSS model group, and PSB intervention (30, 60, and 120 mg/kg) groups. Colitis severity of the mice was assessed by examining body weight changes, disease activity index (DAI), colon length, and histopathology. The expressions of tight junction proteins ZO-1 and claudin-1 in the colon tissues were examined using immunofluorescence staining, and macrophage infiltration and polarization were analyzed with flow cytometry. ELISA and RT-qPCR were used for detecting the expressions of inflammatory factors (TNF‑α and IL-6) and chemokines (CCL

resultsIn DSS-induced mouse models, PSB at 60 mg/kg optimally alleviated colitis, shown by reduced weight loss and DAI scores and increased colon length. PSB treatment significantly upregulated ZO-1 and claudin-1 expressions in the colon tissues, inhibited colonic macrophage infiltration, and promoted the shift of macrophage polarization from M1 to M2 type. In cultured intestinal epithelial cells, PSB significantly inhibited PI3K/AKT phosphorylation and suppressed chemokine CCL

conclusionsPSB alleviates DSS-induced colitis in mice by targeting intestinal epithelial PI3K/AKT signaling, reducing CCL

Indexed as

ColitisFlavanonesInflammatory Bowel DiseasesMacrophagesAnimalsChemokine CCL2ChemotaxisDextran SulfateDisease Models, AnimalEpithelial CellsIntestinal MucosaMaleMiceMice, Inbred C57BLNetwork PharmacologyPhosphatidylinositol 3-KinasesChemokine CCL2Dextran SulfateFlavanonesPhosphatidylinositol 3-KinasespinostrobinProto-Oncogene Proteins c-aktCCL 2colitisdextran sulfate sodiuminfiltration of macrophagesPI3K/AKT signaling pathwaypinostrobin

Identifiers

PMID41139450
PMCPMC12568474

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.